Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity. It most commonly affects adolescent males and may grow into fissures of the. Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male adolescents presentation. % represents % of head and. Angiofibroma nasofaring juvenile – Free download as PDF File .pdf), Text File . txt) or read online for free.
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Case 1 Case 1. JNA being an aggressive tumor may recur posttreatment. Contrast enhanced MRIs are used to achieve avid enhancement with flow voids. Current debate involves the hamartoma and vascular malformation theories. They account for only 0. The classification and clinical staging is relatively easy and helps to plan treatment and determine prognosis. Strayer; Emanuel Rubin See staging of juvenile nasopharyngeal ansofaring.
The location and size of the tumor and feeding vessels are clearly demonstrated by this technique. Type III is a calabash-like massive tumor lobe in the middle cranial fossa.
The final diagnosis is achieved by histopathologic examination of tissue sections either on incisional or excisional biopsy. Support Radiopaedia and see fewer ads. DSA digital subtraction nasofarung of carotid artery to see the extension of tumors and feeding vessels. Hippocrates first described this tumor in the 5 th century B.
This supports the hypothesis that the vascular endothelial cells may become postembryonic undifferentiated mesenchymal cells and can be induced into other mesenchymal nonhemopoitic cell phenotypes.
Sagittal section in computed tomography scans showing site and extent of the lesion. The exact site of origin is contentious as these masses usually present when they have reached considerable size.
Connective tissue was fibro-cellular with irregular pattern and plump fibroblasts [ Figure 6 ]. Findings are similar to those described above. Thus, early diagnosis, accurate staging and adequate treatment are essential in the management of this lesion.
The presentation is typically with obstructive symptoms, epistaxisand chronic otomastoiditis due to obstruction of the Eustachian tube.
JNA is an uncommon, highly vascular, locally invasive, unencapsulated tumor with a distinct predilection for an origin in the nasopharynx of adolescent males. It is, as the name suggests, very vascular and a biopsy can sometimes be fatal.
Indian J Dent Res. J Clin Imaging Sci. Imaging plays an important role in diagnosis, as biopsies should be avoided due to the risk of brisk hemorrhage, as well as staging.
Loss of expression of GSTM 1 null genotype is seen in this tumor. Pancoast tumor Solitary pulmonary nodule Angiofirboma lung Peripheral lung Bronchial leiomyoma. Open in a separate window. However, most authors agree ajgiofibroma JNAs arise from the posterior choanal tissues in the region of the sphenopalatine foramen. Supply of these tumours is usually via Blood vessels were seen in large number at the periphery of the lesion [ Figure 5 ].
Macroscopically this tumor appears as a rounded, circumscribed, noncapsulated mucosa covered mass. Finally, numerous inflammatory cells such as mast cells and T-lymphocytes are seen. Olfactory neuroblastoma Olfactory neuroblastoma. Avid enhancement is noted on contrast-enhanced CT. No encapsulation was noted [ Figure 4 ].
Biopsy should be avoided as to avoid extensive bleeding since the tumor is composed of blood vessels without a muscular coat. Nasopharyngeal carcinoma Nasopharyngeal carcinoma. Accordingly, the treatment options, operative approach and prognosis can be determined. Abstract Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. Plain radiographs no longer play a role in the workup of a suspected juvenile nasopharyngeal angiofibroma, however they may still be obtained in some instances during the assessment of nasal obstruction, or symptoms of sinus obstructions.
Histopathology reveals a fibrocellular stroma with spindle cells and haphazard arrangement of collagen interspersed with an irregular vascular pattern.
J Oral Maxillofac Pathol. He also complained of difficulty in breathing since 6—7 months. Numerical sex chromosome aberrations in juvenile angiofibromas: