Intoxicación por cafeína en un recien nacido prematuro Caffeine citrate is used as first-line therapy in neonates to treat or prevent apnea of prematurity. This is not the most recent version of this Review. Please comment on the current version. view the current version 20 Jan Si su bebé no tenía apnea ni bradicardia en UCIN o si la frecuencia o puede recibir medicamentos (teofilina o cafeína) para disminuir los episodios. Los bebés recién nacidos prematuros corren el riesgo de hernias, que.

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Long-term effects of caffeine therapy for apnea of prrmaturo. Group 1 was formed by 87 newborns and group 2 by Pediatr Clin North Am.

High-pressure liquid chromatography HPLC was the method used to determine caffeine, which has been employed in several studies on caffeine dosage. This study aimed at determining the influence of presence of caffeine in umbilical cord blood on the incidence and time of occurrence of apnea of prematurity in the first days of life.

They were monitored during their stay dwl neonatal intensive care unit for occurrence of apnea spells during the first 4 days of life. No difference was observed in occurrence of apnea between both groups, but diagnosis of apnea was obtained through pneumography, which was performed only after clinical stability and in patients that did not require cafenia support or oxygen therapy, thus excluding patients with serious conditions.

Group characteristics were analyzed using chi-square test, Fisher’s exact test, except for the birth weight variable Student’s t test and Apgar score Mann-Whitney test.

cafeina en apnea del prematuro pdf

A United States national reference for fetal growth. Efficacy rpematuro caffeine in treatment of apnea in the low-birth-weight infant. Simultaneous determination of caffeine and its primary demethylated metabolites in human plasma by high-performance liquid chromatography.


Carlos Gomes, cj. Apnea is associated with neurodevelopmental impairment in very low birth weight infants.

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As caffeine is a substance that crosses the placental barrier, it could have cafwina intrauterine stimulation of the fetus’s respiratory center. Experimental studies showed that recently born rats whose mothers had received caffeine during pregnancy had altered respiratory pattern.

Umbilical blood was collected in preterm neonates; 21 of them were subsequently excluded seven for presenting apnea once with no need for treatment, five for remaining in mechanical ventilation until the fourth day of life, three for PIVH degrees 3 and 4, one for exchange transfusion, five for methylxantine prior to extubationand three were lost two due to insufficient sampled quantity for caffeine dosage and one due to family request.

One limitation of this study is the lack of comparison in the number of apnea spells between both groups. Perinatal respiratory control and its modulation by adenosine and caffeine in the rat. Consequences of in utero exposure on respiratory output in normoxic and hypoxic aapnea and related changes of Fos expression: Prematurity, apnea, caffeine, low-birth-weight infant.

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rn Median caffeine concentration of prematiro 87 patients with detectable caffeine in umbilical blood was 2. Blood samples were collected from umbilical blood using syringes with heparin. The sample was composed of preterm neonates with birth weight between 1, and 2, g and gestational age under 37 weeks, born at HCPA between March and May Concentrations of caffeine and paraxanthine in saliva were measured in pregnant women in the United Kingdom levels of caffeine in plasma and saliva are strongly correlatedand the mean concentration of caffeine was 0.

Birth weight was measured using an electronic scale and the neonates were classified according to the curve of Alexander et al. Some studies quantified maternal use of caffeine during pregnancy. A rapid HPLC method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns.


Discussion This study showed that neonates with detectable and undetectable levels of caffeine in umbilical cord blood had similar occurrence of cafeian, and among anea neonates who presented apnea, occurrence was later in preterm neonates with detectable levels of caffeine.

cafeína – English translation – Spanish-English dictionary

The role of maternal consumption of caffeine and occurrence of apnea in preterm neonates have aroused general interest. Admin Administrateur Offline Joined: The logistic regression model employed for the whole studied population took the presence of caffeine in umbilical cord blood as a dependent factor, and gestational age, occurrence of apnea, use of CPAP and mechanical ventilation as independent factors. La apnea del sueno en el bebe prematuro. Effects of maternal smoking and caffeine habits on infantile apnea: Before the collection and inclusion, a consent term was read to the parents or person in charge.

For the diagnosis of meningitis, those with abnormal cerebrospinal fluid and positive culture were considered. This study showed that neonates with detectable and undetectable levels of caffeine in umbilical cord blood had similar occurrence of apnea, and among the neonates who presented apnea, occurrence was later in preterm neonates with detectable levels of caffeine.

Neonates were divided into detectable and undetectable caffeine in umbilical cord blood. Schreiber-Deturmeny E, Bruguerolle B. Fri 19 Jan – Silveira II ;Renato S.

Diagnosis and management of bacterial infections in the neonate. Caffeine intake and prematurity. None of them showed significance Table 3.