Disease definition. Dystrophic epidermolysis bullosa (DEB) is a form of inherited epidermolysis bullosa (EB) characterized by cutaneous and mucosal fragility. Epidermolysis bullosa (EB) is a group of inherited bullous disorders characterized by blister formation in response to mechanical trauma. EPIDERMOLYSIS BULLOSA DYSTROPHICA, AUTOSOMAL RECESSIVE, LOCALISATA VARIANT, INCLUDED. EPIDERMOLYSIS BULLOSA DYSTROPHICA.

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There are four main types with additional sub-types identified. Esophageal strictures are treated by balloon dilatation with fluoroscopic guidance. Recessive Dystrophic Epidermolysis Bullosa Inversa The inversa subtype of autosomal recessive dystrophic epidermolysis bullosa is a rare variant characterized by lesions involving primarily the flexural areas of the body with sparing of the fingers and toes Wright et al. By definition, inherited EB is a genetically transmitted disorder characterized by marked fragility of the skin.

Premature termination codons on both alleles of the type VII collagen gene COL7A1 in three brothers with recessive dystrophic epidermolysis bullosa. Type VII collagen is susceptible to degradation by collagenase Seltzer et al. Santiago, Chile, International Journal of Dermatology. Clinical Synopsis Toggle Dropdown.

However, clinical dustrophica included blisters, milia, atrophic scarring, nail dystrophy, and oral and conjunctival involvement, as seen in dystrophic EB. Synonyms of Epidermolysis Bullosa EB. Frequence de mutation de la chondrodystrophie et de l’epidermolyse bulleuse dans une population du sud de la Suede.

Mucosal involvement is common and most frequently manifests with oral cavity lesions and esophageal strictures. Progress in epidermolysis bullosa: Recessive dystrophic epidermolysis bullosa RDEB Also known as “Hallopeau—Siemens variant of epidermolysis bullosa” [11] and “Hallopeau—Siemens disease”, [12] this variant dyshrophica from mutations in the gene encoding type VII collagen, COL7A1, characterized by debilitating oral lesions that produce pain, scarring, and microstomia.


Costello syndrome Kindler syndrome Laryngoonychocutaneous syndrome Skin fragility syndrome.


Focal palmoplantar keratoderma with oral mucosal hyperkeratosis Focal palmoplantar and gingival keratosis Howel—Evans syndrome Pachyonychia congenita Pachyonychia congenita type I Pachyonychia congenita type II Striate palmoplantar bbullosa Tyrosinemia type II punctate: Genetic linkage of recessive dystrophic epidermolysis bullosa to the type VII collagen gene.

J Am Acad Dermatol. Type VII collagen mutations and phenotype—genotype correlations in the dystrophic subtypes”. Specialised Social Services Eurordis directory. Friction causes blister formation. The phenotype resembled the human recessive disorder, including skin fragility, nail dystrophy, pseudosyndactyly, and growth retardation.


Type VII collagen deposition could be detected in skin biopsies after treatment, but anchoring fibrils never appeared normal. Hand deformities can be treated surgically, but have a high recurrence. Mitten deformities of the paws were found to result from soft tissue accumulation and contraction due to aberrant fibrosis that accompanied wound healing.

Seven patients had features of both dominant and recessive forms of disease and were found to carry both dominant and recessive mutations.

CC ]. Although her skin bjllosa was equally as severe as her sister’s, she did not develop amyloid nephropathy until the age of 35 years. The microscopic changes were said to be similar to those of the Hallopeau-Siemens form of epidermolysis bullosa. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships.

Dystrophie cutanee buleuse atrophiante et albo-papuloide.

Aplasia cutis congenita Amniotic band syndrome Branchial cyst Cavernous venous malformation Accessory nail of the fifth toe Bronchogenic cyst Congenital cartilaginous rest of the neck Congenital hypertrophy of the lateral fold of the hallux Congenital lip pit Congenital malformations of the dermatoglyphs Congenital preauricular fistula Congenital smooth muscle hamartoma Cystic lymphatic malformation Median raphe cyst Melanotic neuroectodermal tumor of infancy Mongolian spot Nasolacrimal duct cyst Omphalomesenteric duct cyst Poland anomaly Rapidly involuting congenital hemangioma Rosenthal—Kloepfer syndrome Skin dimple Superficial lymphatic malformation Epidefmolysis duct cyst Verrucous vascular malformation Birthmark.


These results supported the idea that certain glycine substitutions in the collagenous domain of COL7A1 cause a limited nail deformity, and that these alleles can also contribute to variable degrees of skin fragility when present in combination with nonsense or frameshift mutations in COL7A1.

Unfortunately, it is not free to produce. Together we are strong. Epidermolysis bullosa dystrophica dominans–ein Defekt der anchoring fibrils? Collagenase expression in skin fibroblasts from families with recessive dystrophic epidermolysis bullosa.

The patients also had blistering of the mucous membranes in the oral cavity and esophageal strictures that caused severe malnutrition and anemia, which led to death in the oldest brother at age 21 years.

All patients had oral involvement, including ankyloglossia, loss of tongue papillae, and obliteration of the oral vestibule between the lips and gingiva.

Investigational Therapies Dystrophiac cell transplant therapy trials for recessive dystrophic epidermolysis bullosa are being conducted at at least two institutions. This results in mutilating scarring and contractures of the hands, feet, and joints.

Rare Disease Database

epiddrmolysis During the neonatal period and infancy it may also include aplasia cutis congenita, herpes simplex infection, epidermolytic ichthyosis, bullous impetigo, staphylococcal scalded skin syndrome, linear IgA bullous dermatosis, bullous pemphigoid, neonatal pemphigus and pemphigoid gestationis see these terms. Autosomal recessive epidermolysis bullosa dystrophica is an allelic disorder. One was 22 years old when the diagnosis of amyloidosis was made.

All studies receiving U.