Fisiologia Renal de Vander – Ebook download as PDF File .pdf) or read book online. Conciso e didático, este livro explora os aspectos fundamentais da fisiologia renal que são essenciais para o bom entendimento da medicina clínica. : FISIOLOGIA RENAL DE VANDER 6TA. EDIC. by EATON DOUGLAS C. () by Douglas C. Eaton and a great selection of similar.
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Combining the latest research with a fully integrated teaching approach, the eighth edition of Fisiiologia Renal Physiology features revised sections that explain how the kidneys affect other body systems and how they in turn are affected by these systems. The goal of his research is to examine the cellular signaling mechanisms which control all aspects of cellular function including cell growth, division, vnaders responses to external stimuli. Regarding tubular sodium handling in the oldest old, it has been documented that the selective reabsorption of sodium at the proximal tubule, evaluated using the Chaimowitz test, shows that it remains in the normal fisuologia On the other hand, serum uric acid level and fractional excretion of uric acid FEUAc do not differ between very old healthy people in comparison with healthy young ones.
TTKG in basal situation, does not show any significant difference between the very old group and the young one, despite the existence of lower glomerular filtration in the very old, which ultimately accounts for the relatively reduced cation excretion fisioogia the very old, since it is known that the potassium excretion tends to increase paralelly to the reduction of glomerular filtration: Written in a clear, concise, logical style, this trusted text reviews the fundamental principles of the structure, function and pathologies of the human kidney that are essential for an understanding of clinical medicine.
Geriatric nephrology and the ‘nephrogeriatric giants’. Creatinine clearance measured without CC or with cimetidine CCWCwhich is almost the same as inuline clearance due to the blocking effect that cimetidine has on renao proximal tubular secretion of creatinine, has proved to be significantly lower in the very old healthy people in comparison to that documented on the younger population[ 1vamders ]: Journal List World J Nephrol v.
The previously described physiological alterations vqnders show that the characteristic senile sodium urinary loss depends not only on the reduced sodium reabsorbed in the TALH but also in the collecting tubules[ 24 ]. Even though, the above mentioned creatinine renal filtration difference between the age groups, there is no significant difference regarding their serum creatinine value between them.
From the clinical point of view, the above mentioned reduction in the tubular capacity to reabsorb sodium fosters sodium depletion and its clinical consequences: This has been attributed to the senile medullar hypotonicity[ 324 ]. As regards the maximum tubular dilution capacity, another of the parameters which Chaimowitz test can evaluate, it has been reported that such dilution is significantly reduced in the very old in comparison with the young: Renal physiology in the healthy oldest old has the following characteristics, in comparison with the renal physiology in the young: The procurement of a ratio between the CC and the CCWC allows for the evaluation of the net tubular handling of this substance: In the present review article, we explain in detail the characteristics of the creatinine, urea, uric acid, sodium, water, and potassium renal handling in the very old healthy people taking the younger group years as a parameter.
Feed-back between geriatric syndromes: Due to the fact that a reduction in the number of urea channels UT1 has been documented in the collecting tubules of very old rats, it could be suggested that the senile increase in urea excretion may be the consequence of a lower reabsorption of urea at the distal tubules[ 17 ].
Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Published online Oct 6. Aldosterone bioactivity in this segment is studied using the furosemide test, which ultimately generates a discrete hypovolemia that stimulates the release of this hormone, which in turn stimulates the secretion of potassium in the collecting tubules. Creatinine reabsorption by the aged kidney.
Additionally, it has also been documented a decrease in sodium reabsorption in the thick ascending loop of Henle in very old healthy people[ 20 ]. Fractional excretion of K, Na and Cl following furosemide infusion in healthy, young and very old people. Renal handling of sodium in old people: Since furosemide stimulates sodium loss due to the inhibition of its reabsorption at the level of the TALH, the lower increase in soduria after furosemide infusion in the very old in comparison with the young could be explained by the functional reduction in the TALH furosemide blocking site due to the senescence process[ 23 – 25 ].
Even nowadays the limits that separate the changes considered typical of the normal ageing process of those patients who suffer from high prevalent illnesses characteristic of this period are not clear.
Since uric acid is mainly handled in the proximal tubule, a segment that suffers practically no functional changes with ageing, perhaps this could explain the above mentioned phenomenon[ 14 ]. Studies in old rats have documented a significant reduction in the number of co-transporters NKCC2 in comparison with young ones.
Biology, functions and diseases. Begins with the basics and works up to advanced principles Focuses on the logic of renal processes Includes the most current research on the molecular and genetic principles underlying renal physiology Explains the relationship between blood pressure and renal function Reanl the normal functions of the kidney with clinical correlations to disease states Includes study questions with an answer key at the end of each chapter Features learning aids such as flow charts, diagrams, key concept clinical fisioogia, boxed statements to emphasize major points, learning objectives, and review questions with answers and explanations About the Authors Doug Eaton is the Distinguished Professor and Chairman of Physiology at Emory University.
Fractional excretion of urea in severely dehydrated elderly with dementia. Anatomical changes in the aging kidney. Examination of kidney function. These finding could be interpreted as the fact that the dehydration over expresses the habitual senile creatinine back-filtration. The observed difference in the creatinine filtration between the studied age groups could be justified as a consequence of the decrease in the number of glomerular units secondary to their obliteration due to the glomeruloscrerosis which accompanies ageing[ 3 – 5 ].
Dysfunction of the thick loop of Henle and senescence: Aging and physiological changes of the kidneys including changes in glomerular filtration rate. This lower local sodium reabsorption, leads to the following alterations[ 8 ]: Author information Article notes Copyright and License information Disclaimer.
To examine these signaling mechanisms, he uses contemporary methods of cellular and molecular biology including patch voltage clamp methods and expression of cloned signaling molecules in Xenopus oocytes and other expression systems. Each chapter is filled with the tools you need to truly learn key concepts rather than merely memorize facts.
Additionally, it is important to point out that there are no significant physiological differences related to gender in flsiologia age populations. Martinus Nijhoff Publisher; Creatinine reabsorption by the newborn rabbit kidney. The aging kidney in health and disease.