Range Description: The species is present in the Mediterranean region (southern Europe, western Asia and northern Africa), especially on the western side (e.g. Category: cosmetic ingredient for skin conditioning. Recommendation for globularia alypum leaf extract usage levels up to: not for fragrance use. Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and.

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GA is widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying its use. For the extinct genus of sea snails, see Globularia.

Since, on the one hand, androgens are known to possess anabolic effects by increasing protein synthesis from amino acids[ 22 — 24 ] and to cause glucose metabolism troubles with insulin resistance[ 2526 ] on the other hand, it is therefore possible to attribute that the recorded active spermatogenesis could result from an androgenic effect induced by the drug. Study of packed cell volume and erythropoietin responses. From Wikipedia, the free encyclopedia.

Likewise, it has not been noted any concerning food and water consumption between G. The acute toxicity study showed that when G. The white pulp was of variable size whereas the red pulp was congestive with stasis and siderosis [ Figure 4b ]. This Lamiales article is a stub. The study of acute toxicity performed on mice demonstrated that the toxicity G. Ben Merabet K, Abed A. A group served as the control group received vehicle water. Hypoglycaemic effect of Rubus fructicosis L.

J Acquir Immune Defic Syndr. However, daily clinical examination showed the appearance of liquid stools from D 5 to D 25 that were more pronounced in female than in male rats.

Taking into alypmu the fact that the erythropoietin source is practically exclusively renal in rat[ 20 ] and that androgens are described as possessing a trophy effect on kidneys,[ 21 ] it is therefore possible to conclude to an androgen-like action of G. Table 4 Spermatogenesis study after administration by the oral route of Globularia alypum L. Histological examination of female organs did not show any particularity.


Feb, [Retrieved on Nov 24]. Through an intra-peritoneal route, G. Globulariaceae is a akypum growing in the Mediterranean basin and known to be used as a popular medicine for its several pharmacological properties against rheumatism, gout, typhoid, intermittent fever, and diabetes. Fehri B, Aiache JM. Active spermatogenesis, acute and chronic toxicity, androgenic properties, Globularia alypum L. A total of 17 compounds were identified.

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The second one is represented by the recorded dose-dependent hyperlipemia observed in males and the hypercholesterolemia that occurred in males and females. Acute toxicity study in mice The determination of the acute toxicity of G. Spermatogenesis study after administration by the oral route of Globularia alypum L. The determination of the acute toxicity of G.

Histological examination of this organ showed the existence of a pronounced thinning of pulmonary arteriolar wall meaning the presence of histological grades I to II pulmonary hypertension PHT [ Figure 4a ].

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It has not also been observed any fibrosis or siderosis. In vitro antioxidant effect of Globularia alypum L. The concentration of globularin in the aqueous extract was of Articles with ‘species’ microformats All stub articles.

This data may also confirm the low toxicity of the drug. Oxandrolone in the treatment of HIV-associated weight loss in men: Two more results argue in favor of G.

J Sci Med Sport. The drug, dissolved in water, has been administrated by oral and intra-peritoneal routes to ten mice groups according to doses chosen in geometrical progression of 1: In this respect, G.

Globulariaceae is a widely growing shrub in the Mediterranean area known for its uses in popular medicine for several properties: The homogenate was centrifuged for 30 min at g and the supernatant filtered and lyophilized. During the treatment period, a control group of 10 male rats weighing Badreddine Fehri, Boite Postale B. Results of histological examination Histopathological examination of the organs removed at the end of the treatment revealed, in comparison with the control groups, the tlobularia of golbularia histological modifications induced by the chronic administration of the drug.


Although the mechanism of action of androgens on lipids metabolism is not totally elucidated, it is reported that androgens may cause dyslipidemia,[ 26 ] can activate adipocytes lipase[ 27 ] and increase the release of free fatty acids. Anemia induces accumulation of erythopoietin in the kidney and the liver. This effect was followed by an increase of cardiac pulse rate from Plants have been considered as potential agents for prevention and treatment of disorders in recent years.

Globularia alypum L., – Turbith – Overview

Hematocrit and hemoglobin were respectively determined by means of the gravity and cyanmethemoglobin method. Concentrations of blood glucose, cholesterol and triglycerides were determined by enzymatic methods Sera Pak Kits, Ames, Italia.

Alterations in hepatic lipase and lipoproteins subfractions with transdermal testosterone replacement gllobularia. Muscular strength, body composition and health responses globulatia the use of testosterone enanthate: Thus, this study confirms its traditional use, however further more precise studies are needed for future clinical application.

Investigations carried out during the treatment period During the treatment period, the animals were clinically followed up, daily weighed, determination of food and water consumption, measure of blood pressure and cardiac pulse rate at root tail level with a B. Moreover, with globulari exception of the red pulp that was found congestive with stasis and siderosis, in general, the normal histological structure of the spleen was preserved.

Histopathological examination of the organs removed at the end of the treatment revealed, in comparison with the control groups, the existence of important histological modifications induced by the chronic administration of the drug.