J Reprod Med. Sep;47(9) Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. Heller DS (1). Case Report. Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma. Ineke Janse1*, Gilles Diercks1,2, Jan Doff2, Marian Mourits3 and. Vulvar Hidradenitis Suppurativa: Is the Mass. Malignant? Siew-Fei Ngu, MBBS;1 Mandy M. Y. Chu, MBBS;1 Philip P. C. Ip, MBChB;2. Hextan Y. S. Ngan, MD1.

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A chronic, relapsing, suppurative inflammation of the terminal vulvqr follicle in areas of apocrine glands: Lysozyme stained apocrine glands, but this was not a consistent finding.

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If the affected skin area is small enough, it may be possible to surgically remove the entire area, which will cure the disease. The pathophysiology of the disease involves follicular occlusion, follicular rupture, with vullvar associated immune response that leads to the formation of abscesses, sinus tracts, scarring, and ultimately severe diffuse involvement Pena et al.

The Hirradenitis Cause of Vulva Carcinoma. Published online Mar To our best knowledge, it has been reported in at least 64 cases Alikhan et al. The patient’s external genitalia showed areas affected by severe, chronic hidradenitis suppurativa with marked hyperkeratosis with darkened areas of fibrosis.

Pathology Outlines – Hidradenitis suppurativa

Patient underwent a vulvar biopsy which revealed a focus of a well-differentiated, keratinizing squamous cell carcinoma. Articles from Gynecologic Oncology Reports are provided here courtesy of Elsevier.


The case in our paper of HS associated with vulvar SCC emphasizes that women can also develop this complication. CD15 also was reliable for apocrine differentiation. An abscess was suspected in the context of a HS whereupon a general surgeon performed an incision and drainage.

Following good uidradenitis care practices also helps. Skin inflammatory nontumor Infectious disorders Hidradenitis suppurativa Author: A physical examination uncovered a 2 cm diameter verrucous tumor on an erythematous, enlarged, diffuse infiltrated labium majus on a background of HS Hurley stage III with scarring and sinus tract formation Figure 1.

S stained only the secretory clear cells of the eccrine glands. A retrospective review of the histology of resections for vulvar HS was performed, and a battery of immunohistochemical stains was performed.

Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma

However, tests for infection are usually negative, antibiotics do not help, and the lumps often come back after surgery. Vulfar Painful lumps can be lanced, or injected with cortisone.

Pharmacologic methods include topical clindamycin as first-line therapy, topical resorcinol a chemical peeling agentintralesional corticosteroids or systemic antibiotics. Status post wound revision secondary to wound separation and infection.

Hidrsdenitis definite lymphovascular space invasion was identified. SCC is a rare but severe complication of HS. Discussion Our case highlights a rare consequence of long-standing poorly controlled hidradenitis suppurativa: Early recognition is important where the prognosis of vulvar cancer is associated with lymph node metastases in the groin and tumor size [5]. Being overweight makes HS worse as well.


This website is intended for pathologists and laboratory personnel, who understand that medical information is hidradenitks and must be interpreted using reasonable medical judgment. Apocrine glands, when present, were away from active inflammation.

Eccrine glands accounted for the majority of glands in all cases. Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa.

Squamous cell carcinoma in the setting of chronic hidradenitis hidrzdenitis report of a patient and update of the literature. Three fatal cases of squamous cell carcinoma arising in chronic perineal hidradenitis suppurativa.

B Well-differentiated squamous cell carcinoma SCC. Journal List Gynecol Oncol Rep v.

Fibrosis was variable but was greater with less inflammation, suggesting a later stage in disease evolution. This regimen resulted in significant improvement in healing of the surgical wound.

Histopathology showed negative SN and clear jidradenitis. Squamous cell carcinoma arising in hidradenitis suppurativa. Case Report Hidradenitis Suppurativa: Inflammation of the glands was often absent or minimal and seen only with associated poral occlusion.